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The circulation of the EURO currency in EMU in 2002 and the global financial crises that broke out in 2008 have triggered changes in the financial institutions and their performance worldwide and mainly in Europe. This paper exami nes the internal and external determinants of the banks that define their performance. By creating an unbalanced panel dataset of 456 observations gained from a sample of 32 commercial, active and lived banks located in the United Kingdom, we defined the i mpacts of the aforementioned determinants on the two measures of bank performance: ROAA and NIM. According to our findings both, EURO currency and financial crisis had influenced negatively British banking sector. The findings are not always the expected o nes and differ between the two measures of profitability, even though between the two different large - scale events. The capital strength has a significant and positive impact on bank profitability, though costs and low quality loans affect negatively bank profitability. The macroeconomic variables have volatile effects depending on the performance measure and the inserted dummy variable in our models.