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This Dissertation thesis focuses on CFD simulation of natural ventilation in Municipal Aquatic Center of Kozani. The outcome of previous work (measurements and calcula-tions) is used as input. Accordingly, the distribution of temperature, pressure, air veloci-ty and CO2 concentration is calculated. This combination of measurements, 1D and CFD approaches provide an integrated solution to the problem of ventilation calculation This could compromise a good step in the design of aquatic centers. CFD approach gives the opportunity to find out the optimum openings, their size and their position, in order to achieve comfort condition for the users of the natatorium. The weak spots of design are revealed, and they could be improved.