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This dissertation was written as part of the MSc in E-Business and Digital Marketing at the International Hellenic University. The emergence of the COVID-19 pandemic in late 2019 in China is a global challenge with incalculable consequences in social, economic and political terms. Many researchers have tried to interpret the consequences of this phenomenon and how it can affect various areas of human life. For many sectors of the economy, the dominant question is whether the outbreak of the virus can be turned into an opportunity. This research evaluates the effects on e-commerce and e-commerce and analyzes the theoretical background and previous research conducted so far. At the same time, reference is made to the events that have taken place so far, to the timeline of the outbreak of the virus and its effects on the e-commerce and e-transactions. The research focuses on Greece and the measures taken by the Government (Policy Responses, 2020) to deal with the first wave of the pandemic. The research is based on the extended version of the UTAUT model and explores the influence of factors such as familiarity with technology and the social impact on consumers' intention to use e-commerce. Research findings show that factors related to technology and social influence play a key role in consumer decision making. In addition, safety and expected performance are key variables. The research is conducted in the area of Thessaloniki, which limits its geographical scope, while the fact that it is conducted over a period of time makes it impossible to draw long-term conclusions.