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This dissertation was written as part of the MSc in Management at the International Hellenic University. Information and Communication Technologies (ICTs) in tourism, started a new era in contemporary tourism, and hospitality industry. Enterprises in a variety of sectors might utilize AI to steal in yearly revenue from their less-informed competitors and there is no denying the widespread use of AI. There are a variety of ways in which artificial intelligence (AI) is put to use in the tourist sector, including the enhancement of individualization, the provision of more specific suggestions to clients, and the assurance of speedy responses even when human operators are unavailable. The goal of this study, is to find, analyze and evaluate the spread of published articles (reports, case studies, dissertations etc.) in the literature about the influence of Artificial Intelligence in the tourism industry and also specifically in Greece. We conducted a Systematic Literature Review” approach with the use of Prisma Methodology. The search was done in the Web of Science database from 01/01/2000 until 12/31/22 with these the key words “AI and Tourism”, “Artificial Intelligence and Tourism”, “AI Applications and Tourism”. According to the study's results, the benefits of the newly developed AI approach include "increased accuracy of classification and prediction," "development of smart tourist platforms," and "quick operations under unanticipated events. Greek applications seem to focus mainly in the machine learning department and artificial neural networks with some references to the use of Big Data and a single reference about Customized AI Apps.